Also known as Sanqi or Tianqi in China for over 650 years, Panax Notoginseng is commonly referred to as the “King of Ginsengs” because its active compounds are superior to other ginseng family members in quantity in addition to its own unique notoginsenoside. It is featured in nearly every patented herbal medicine formula in China. Traditionally, it is used as a hemostatic medicine to control internal and external bleeding for hundreds of years. According to the theory of traditional Chinese medicine, notoginseng is sweet, bitter in flavor, and enters the “heart,” “pericardium,” and “liver” channels which functions in nourishing blood, benefiting Qi, and activating blood circulation of the whole body. Modern researchers have discovered that notoginseng contains a variety of nutrients including saponins, panaxytriol, polysaccharides, amino acids, flavonoids, β-sitosterol, fatty acids, etc. Among them, saponins play a vital role in its multiple biological activities. To date, twenty-seven saponins were identified and nine of them including notoginsenosideR1, ginsenoside Rb1, Rb2, Rb3, Rc, Rd, Re, Rf, and Rg1 were quantified.