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JointEase with UC•II™ - Clinical Studies

• Study 1: In the first Harvard study, six of ten patients taking undenatured type II collagen for three months showed substantial improvement, while one patient recovered completely. In addition, there were no side effects.

  Trentham, et al., "Effects of Oral Administration of Type II collagen on Rheumatoid Arthritis", Science, 261:1727-1730, 1993

• Study 2: In a 90-day, double-blind, placebo-controlled, follow-up study on patients with severe rheumatoid arthritis, 28 patients taking undenatured type II collagen showed significant improvement compared to he placebo group, while four patients recovered completely.

  Trentham, et al., "Effects of Oral Administration of type-II collagen on Rheumatoid Arthritis", Science, 261:1720-1730, 1993

• Study 3: A third Harvard study showed that after three months of treatment with undenatured type II collagen, eight of ten patients with juvenile rheumatoid arthritis had a reduction in both swollen and tender joints.

  Barnett, et al., "A Pilot trial of Oral Type II Collagen in the Treatment of Juvenile Rheumatoid Arthritis", Arthritis & Rheumatism, 39:623-628, 1996

• Study 4: A fourth Harvard study showed that, following treatment with undenatured type II collagen, 21 of 54 arthritis patients (39%) who met the cumulative Paulus criteria (morning stiffness, joint tenderness, joint swelling and erythrocyte sedimentation rate) demonstrated significant improvement, while only 11 of 57 patients (19%) taking a placebo showed improvement.

  Barnett, et al., "Treatment of Rheumatoid Arthritis with Oral Type II collagen. Results of Multicenter, Double-Blind, Placebo-Controlled Trial", Arthritis & Rheumatism, 41:290-297, 1998

• Study 5: Two studies out of Germany have reported similar results. In the first study, there was “a higher prevalence of responders in the type II collagen-treated groups: seven responders in the 10-mg type II collagen group and six in the 1-mg group, versus four in the placebo group. Furthermore, three patients in the 1—mg group and one patient in the 1-mg group and no patients in the placebo group, had very good response.

  Sieper, et al., "Oral Type II Collagen Treatment in Early rheumatoid Arthritis. A Double-Blind, Placebo-Controlled, Randomized Trial", Arthritis & Rheumatism, 39:41-50, 1996

• Study 6: In the second German study, 1mg and 10 mg doses of undenatured type II collagen results in reduced collagen type II antibody titres, but only in those patients showing a clinical response. The study also showed that the 10 mg dose level was more effective than the 1 mg dose level.

  Gimsa, et al., "Type II collagen Serology: A Guide to Clinical Responsiveness to Oral Tolerance?", Rheumatology International, 16:237-240, 1997